| Product Includes | Product # | Quantity | Mol. Wt | Isotype/Source |
|---|---|---|---|---|
| AMPA Receptor 1 (GluA1) (D4N9V) Rabbit mAb | 13185 | 20 µl | 100 kDa | Rabbit IgG |
| AMPA Receptor 2 (GluA2) (E1L8U) Rabbit mAb | 13607 | 20 µl | 100 kDa | Rabbit IgG |
| AMPA Receptor 3 (GluA 3) (D47E3) Rabbit mAb | 4676 | 20 µl | 100 kDa | Rabbit IgG |
| AMPA Receptor 4 (GluA 4) (D41A11) XP® Rabbit mAb | 8070 | 20 µl | 100 kDa | Rabbit IgG |
| Phospho-AMPA Receptor 1 (GluA1) (Ser845) (D10G5) Rabbit mAb | 8084 | 20 µl | 100 kDa | Rabbit IgG |
| Phospho-AMPA Receptor 2 (GluA2) (Tyr869/Tyr873/Tyr876) Antibody | 3921 | 20 µl | 100 kDa | Rabbit |
| Anti-rabbit IgG, HRP-linked Antibody | 7074 | 100 µl | Goat |
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Description
The AMPA Receptor (GluA) Antibody Sampler Kit provides an economical means of evaluating the four subunits of AMPARs. The kit contains enough primary and secondary antibodies to perform two western blot experiments with each antibody.
Storage
Background
AMPA- (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid), kainate-, and NMDA- (N-methyl-D-aspartate) receptors are the three main families of ionotropic glutamate-gated ion channels. AMPA receptors (AMPARs) are comprised of four subunits (GluR 1-4), which assemble as homo- or hetero-tetramers to mediate the majority of fast excitatory transmissions in the central nervous system. AMPARs are implicated in synapse formation, stabilization, and plasticity (1). In contrast to GluR 2-containing AMPARs, AMPARs that lack GluR 2 are permeable to calcium (2). Post-transcriptional modifications (alternative splicing, nuclear RNA editing) and post-translational modifications (glycosylation, phosphorylation) result in a very large number of permutations, fine-tuning the kinetic properties of AMPARs. Research studies have implicated activity changes in AMPARs in a variety of diseases including Alzheimer’s, amyotrophic lateral sclerosis (ALS), stroke, and epilepsy (1).
Background References
Trademarks and Patents
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