13.2
#O54824
16170
Background
Interleukin 16 (IL-16) is pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication (1-4). IL-16 is associated with the development of multiple sclerosis, an inflammatory demyelinating disease of the central nervous system (5). Studies have shown that there is increased expression of IL-16 in the brain and spinal cord tissues of experimental autoimmune encephalomyelitis (EAE) mice compared to immunized controls. This resulted in recruitment and activation of CD4+ immune cells in the neuroinflammation associated with multiple sclerosis (5). IL-16 is a 17 kDa peptide that interacts with its receptor, the CD4 antigen, and functions as a growth factor specifically for CD4+ T cells. This pleiotropic cytokine is known to play a role in immunodeficiency diseases, such as AIDS (6).
- Cruikshank, W. and Center, D.M. (1982) J Immunol 128, 2569-74.
- Center, D.M. et al. (1983) J Immunol 131, 1854-9.
- Shimokawa, Y. et al. (1984) Immunology 51, 275-85.
- Cruikshank, W.W. et al. (2000) J Leukoc Biol 67, 757-66.
- Hridi, S.U. et al. (2021) Biology (Basel) 10, 472. doi: 10.3390/biology10060472.
- Cruikshank, W.W. et al. (1998) Int Rev Immunol 16, 523-40.
Endotoxin
Endotoxin levels are less than or equal to 1 EU / 1 μg mIL-16.
Purity
A greater than or equal to 95% purity was determined by SDS-PAGE.
Source / Purification
Recombinant mouse IL-16 was expressed in E. coli and is supplied in a lyophilized form.
Background
Interleukin 16 (IL-16) is pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication (1-4). IL-16 is associated with the development of multiple sclerosis, an inflammatory demyelinating disease of the central nervous system (5). Studies have shown that there is increased expression of IL-16 in the brain and spinal cord tissues of experimental autoimmune encephalomyelitis (EAE) mice compared to immunized controls. This resulted in recruitment and activation of CD4+ immune cells in the neuroinflammation associated with multiple sclerosis (5). IL-16 is a 17 kDa peptide that interacts with its receptor, the CD4 antigen, and functions as a growth factor specifically for CD4+ T cells. This pleiotropic cytokine is known to play a role in immunodeficiency diseases, such as AIDS (6).
Background References
Cross-Reactivity Key
H: human M: mouse R: rat Hm: hamster Mk: monkey Vir: virus Mi: mink C: chicken Dm: D. melanogaster X: Xenopus Z: zebrafish B: bovine Dg: dog Pg: pig Sc: S. cerevisiae Ce: C. elegans Hr: horse GP: Guinea Pig Rab: rabbit All: all species expected
Trademarks and Patents
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