19.9
#Q80XI9, #Q14623
16147, 3549
Background
Indian hedgehog (Ihh) is a cell signaling protein that is one of the three proteins in the hedgehog family (1-3). Ihh is expressed in adult kidney and liver and acts as an antagonist of the Wnt signaling pathway in colon cancers (1,2). The Wnt signaling pathway plays a role in carcinogenesis and in embryonic development, and any gene mutations in this pathway lead to various diseases (2,4-6). The Ihh protein is involved in chondrocyte differentiation, proliferation, and maturation especially during endochondral ossification, and is a regulator of bone growth (7).
- Marigo, V. et al. (1995) Genomics 28, 44-51.
- van den Brink, G.R. et al. (2004) Nat Genet 36, 277-82.
- Kumar, S. et al. (1996) Genetics 142, 965-72.
- Nusse, R. and Varmus, H.E. (1992) Cell 69, 1073-87.
- Logan, C.Y. and Nusse, R. (2004) Annu Rev Cell Dev Biol 20, 781-810.
- Komiya, Y. and Habas, R. (2008) Organogenesis 4, 68-75.
- Vortkamp, A. et al. (1996) Science 273, 613-22.
Endotoxin
Endotoxin levels are less than or equal to 1 EU / 1 μg h/mIhh.
Purity
A greater than or equal to 95% purity was determined by SDS-PAGE.
Source / Purification
Recombinant human/mouse Ihh was expressed in E. coli and is supplied in a lyophilized form.
Background
Indian hedgehog (Ihh) is a cell signaling protein that is one of the three proteins in the hedgehog family (1-3). Ihh is expressed in adult kidney and liver and acts as an antagonist of the Wnt signaling pathway in colon cancers (1,2). The Wnt signaling pathway plays a role in carcinogenesis and in embryonic development, and any gene mutations in this pathway lead to various diseases (2,4-6). The Ihh protein is involved in chondrocyte differentiation, proliferation, and maturation especially during endochondral ossification, and is a regulator of bone growth (7).
Background References
Cross-Reactivity Key
H: human M: mouse R: rat Hm: hamster Mk: monkey Vir: virus Mi: mink C: chicken Dm: D. melanogaster X: Xenopus Z: zebrafish B: bovine Dg: dog Pg: pig Sc: S. cerevisiae Ce: C. elegans Hr: horse GP: Guinea Pig Rab: rabbit All: all species expected
Trademarks and Patents
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