22.5
#P55075, #P37237
2253, 14179
Background
FGF-8 is a member of the large and diverse fibroblast growth factor (FGF) family of peptide growth factors. FGF-8 binds to receptor FGFR1 and functions as a signaling molecule that is involved in many important processes (1,2). FGF-8 is involved in the development of the forebrain and also plays a role in maxillofacial diseases (3,4). It regulates craniofacial structure formation including the teeth, palate, mandible, and salivary glands and decreased expression of FGF-8 results in malformations such as absence of molar teeth, failure to close the palate, and decreased mandible size (4).
Endotoxin
Endotoxin levels are less than or equal to 1 EU / 1 μg h/mFGF-8.
Purity
A greater than or equal to 95% purity was determined by SDS-PAGE.
Source / Purification
Recombinant human/mouse FGF-8 was expressed in E. coli and is supplied in a lyophilized form.
Bioactivity
The bioactivity of recombinant h/mFGF-8 was determined in an NR6R-3T3 cell proliferation assay. The ED50 of each lot is less than or equal to 150 ng/mL.
Background
FGF-8 is a member of the large and diverse fibroblast growth factor (FGF) family of peptide growth factors. FGF-8 binds to receptor FGFR1 and functions as a signaling molecule that is involved in many important processes (1,2). FGF-8 is involved in the development of the forebrain and also plays a role in maxillofacial diseases (3,4). It regulates craniofacial structure formation including the teeth, palate, mandible, and salivary glands and decreased expression of FGF-8 results in malformations such as absence of molar teeth, failure to close the palate, and decreased mandible size (4).
Background References
Cross-Reactivity Key
H: human M: mouse R: rat Hm: hamster Mk: monkey Vir: virus Mi: mink C: chicken Dm: D. melanogaster X: Xenopus Z: zebrafish B: bovine Dg: dog Pg: pig Sc: S. cerevisiae Ce: C. elegans Hr: horse GP: Guinea Pig Rab: rabbit All: all species expected
Trademarks and Patents
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