23.4
#P31371
2254
Background
Fibroblast growth factor (FGF)-9 is a member of the larger FGF family of proteins that play key roles in development, cancer, and metabolism. Binding of FGF-9 to its receptor requires interaction with heparin and induces receptor dimerization, subsequent transphosphorylation, and downstream activation of Erk, Akt, and PLCγ pathways (1). FGF-9 is important for organ development and bone repair (2-4).
Endotoxin
Endotoxin levels are less than or equal to 1 EU / 1 μg hFGF-9.
Purity
A greater than or equal to 95% purity was determined by SDS-PAGE.
Source / Purification
Recombinant human FGF-9 was expressed in E. coli and is supplied in a lyophilized form.
Bioactivity
The bioactivity of recombinant hFGF-9 was determined in an NR6R-3T3 cell proliferation assay. The ED50 of each lot is less than or equal to 2 ng/ml.
Background
Fibroblast growth factor (FGF)-9 is a member of the larger FGF family of proteins that play key roles in development, cancer, and metabolism. Binding of FGF-9 to its receptor requires interaction with heparin and induces receptor dimerization, subsequent transphosphorylation, and downstream activation of Erk, Akt, and PLCγ pathways (1). FGF-9 is important for organ development and bone repair (2-4).
Background References
Cross-Reactivity Key
H: human M: mouse R: rat Hm: hamster Mk: monkey Vir: virus Mi: mink C: chicken Dm: D. melanogaster X: Xenopus Z: zebrafish B: bovine Dg: dog Pg: pig Sc: S. cerevisiae Ce: C. elegans Hr: horse GP: Guinea Pig Rab: rabbit All: all species expected
Trademarks and Patents
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