Background
Tigecycline, also known as GAR-936, is a broad spectrum glycylcycline antimicrobial that binds to the bacterial 30S ribosome, blocking the entry of transfer RNA. This prevents protein synthesis and limits bacterial growth. Tigecycline has a 9-t-butyl-glycylamido side chain on the central skeleton, giving it the ability to overcome most tetracycline resistance mechanisms (1). In vitro studies have shown that Tigecycline has activity against multidrug-resistant Gram-negative and -positive bacteria, vancomycin-resistant enterococci (VRE), methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus epidermidis (MRSE), and penicillin-resistant Streptococcus (1,2). Studies have also found that Tigecycline can selectively kill human leukemia stem and progenitor cells with no disruption to normal hematopoietic cells (3). This small compound has been shown to induce apoptosis and inhibit cell proliferation in cervical cancers by suppressing the Wnt/β-catenin signaling pathway (4).
Molecular Formula
C29H39N5O8
Molecular Weight
585.7 g/mol
Purity
>98%
CAS
220620-09-7
Solubility
Soluble in DMSO at 25 mg/ml.
Storage
Directions for Use
Tigecycline is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 10 mg of powder in 1.13 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.
Background References
Cross-Reactivity Key
H: human M: mouse R: rat Hm: hamster Mk: monkey Vir: virus Mi: mink C: chicken Dm: D. melanogaster X: Xenopus Z: zebrafish B: bovine Dg: dog Pg: pig Sc: S. cerevisiae Ce: C. elegans Hr: horse GP: Guinea Pig Rab: rabbit All: all species expected
Trademarks and Patents
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