Santacruzamate A (CAY10683) (#69552) Datasheet Without Images Cell Signaling Technology

For Research Use Only. Not for Use in Diagnostic Procedures.

Background

Santacruzamate A (CAY10683) is a cytotoxin isolated from the Panamanian marine cyanobacterium cf. Symploca sp., and is a highly selective inhibitor of histone deacetylases (HDACs), specifically HDAC2 (IC₅₀ = 0.119 nM) and HDAC6 (IC₅₀ = 434 nM) (1). This small molecule has been shown to induce apoptosis via transcriptional inhibition of HDAC2, resulting in an increase of p21 Waf1/Cip1 and p19INK4d expression when combined with an HDAC1 inhibitor (2). Santacruzamate A (CAY10683) has also demonstrated the ability to attenuate amyloid-β protein (Aβ) fragment (Aβ_25-35)-induced toxicity through enhancing endoplasmic reticulum (ER) stress tolerance in mice (3). Additionally, HDAC2 has been recognized as a host immune response to the influenza A virus (IVA) and several other viruses, making HDAC inhibitors important compounds to study in relation to viral diseases (4,5).

Molecular Formula

C₁₅H₂₂N₂O₃

Molecular Weight

278.4 g/mol

Purity

>98%

CAS

1477949-42-0

Solubility

Soluble in DMSO at 25 mg/ml or ethanol at 20 mg/ml.

Storage

Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 2 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Directions for Use

Santacruzamate A (CAY10683) is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 1.19 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Background References

Cross-Reactivity Key

H: human M: mouse R: rat Hm: hamster Mk: monkey Vir: virus Mi: mink C: chicken Dm: D. melanogaster X: Xenopus Z: zebrafish B: bovine Dg: dog Pg: pig Sc: S. cerevisiae Ce: C. elegans Hr: horse GP: Guinea Pig Rab: rabbit All: all species expected

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