MCC-950 (sodium salt) (#86428) Datasheet Without Images Cell Signaling Technology

For Research Use Only. Not for Use in Diagnostic Procedures.

Background

MCC-950 (sodium salt), also known as CRID3, is a potent and selective NOD-like receptor (NLR) family pyrin domain-containing protein 3 (NLRP3) inhibitor. NLRP3 is an inflammasome-forming NLR that activates caspase-1, leading to maturation of IL-1β and IL-18 (1). MCC-950 (sodium salt) inhibits IL-1β production in mouse bone marrow-derived macrophage (BMDM) cells with an IC₅₀ value of 7.5 nM (2). The NLRP3 inflammasome is involved in different diseases such as Parkinson’s disease (PD), multiple sclerosis (MS), type 2 diabetes, and atherosclerosis, making MCC-950 (sodium salt) an important compound when studying different autoinflammatory and autoimmune diseases (2,3).

Molecular Formula

C₂₀H₂₃N₂O₅S • Na

Molecular Weight

426.5 g/mol

Purity

>98%

CAS

256373-96-3

Solubility

Soluble in DMSO at 40 mg/ml or water at 30 mg/ml.

Storage

Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Directions for Use

MCC-950 (sodium salt) is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.17 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Background References

Cross-Reactivity Key

H: human M: mouse R: rat Hm: hamster Mk: monkey Vir: virus Mi: mink C: chicken Dm: D. melanogaster X: Xenopus Z: zebrafish B: bovine Dg: dog Pg: pig Sc: S. cerevisiae Ce: C. elegans Hr: horse GP: Guinea Pig Rab: rabbit All: all species expected

Trademarks and Patents

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