Revision 1

#93852

Store at -20C

Olaparib (AZD2281)

5 mg

CST Logo
Orders:

877-616-CELL (2355)

[email protected]

Support:

877-678-TECH (8324)

Web:

3 Trask Lane | Danvers | Massachusetts | 01923 | USA

For Research Use Only. Not for Use in Diagnostic Procedures.

Background

Olaparib (AZD2281) is a potent and selective PARP-inhibitor, specifically targeting PARP1 and PARP2 (IC50 = 5 nM and 1 nM, respectively) (1). This small molecule has synergistic effects on breast cancer cell lines when combined with other treatments, independent of BRCA1 status (2). Non-small cell lung cancer (NSCLC) cancer cells that are homologous recombination (HR)-deficient are hypersensitive to Olaparib (AZD2281) treatment, resulting in reduced cell viability (3).

Molecular Formula

C24H23FN4O3

Molecular Weight

434.5 g/mol

Purity

>98%

CAS

763113-22-0

Solubility

Soluble in DMSO at 33 mg/ml or ethanol at 1.7 mg/ml.

Storage

Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Directions for Use

Olaparib (AZD2281) is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.15 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Background References

Trademarks and Patents

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

All other trademarks are the property of their respective owners. Visit cellsignal.com/trademarks for more information.

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Orders: 877-616-CELL (2355) • [email protected] • Support: 877-678-TECH (8324) • [email protected] • Web: cellsignal.com
For Research Use Only. Not for Use in Diagnostic Procedures.