| Product Includes | Product # | Quantity | Mol. Wt | Isotype/Source |
|---|---|---|---|---|
| CTGF (D8Z8U) Rabbit mAb | 86641 | 20 µl | 35 kDa | Rabbit IgG |
| CYR61 (D4H5D) XP® Rabbit mAb | 14479 | 20 µl | 41 kDa | Rabbit IgG |
| IGFBP3 (D1U9C) Rabbit mAb | 25864 | 20 µl | 40 kDa | Rabbit IgG |
| Integrin β2 (D4N5Z) Rabbit mAb | 73663 | 20 µl | 95 kDa | Rabbit IgG |
| Survivin (71G4B7) Rabbit mAb | 2808 | 20 µl | 16 kDa | Rabbit IgG |
| Axl (C89E7) Rabbit mAb | 8661 | 20 µl | 138 kDa | Rabbit IgG |
| Pan-TEAD (D3F7L) Rabbit mAb | 13295 | 20 µl | 50, 53, 55, 60 kDa | Rabbit IgG |
| Lamin B2 (D8P3U) Rabbit mAb | 12255 | 20 µl | 68 kDa | Rabbit IgG |
| Anti-rabbit IgG, HRP-linked Antibody | 7074 | 100 µl | Goat |
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Description
The YAP/TAZ Transcriptional Targets Antibody Sampler Kit provides an economical means of detecting proteins whose transcription is subject to regulation by the transcriptional co-activators YAP and/or TAZ. The kit provides enough antibody to perform two western blot experiments with each primary antibody.
Storage
Background
YAP and TAZ (WWTR1) are transcriptional co-activators that play a central role in the Hippo Signaling pathway that regulates cell, tissue and organ growth. Under growth conditions, YAP and TAZ are translocated to the nucleus, where they interact with DNA-binding transcription factors (e.g., Transcriptional Enhanced Activation Domain [TEAD] proteins) to regulate the expression of genes that control fundamental aspects of cell function, such as proliferation and cell survival (1). A number of genes have been experimentally confirmed as targets of transcriptional regulation by YAP and TAZ. These include the extracellular matrix proteins CTGF, CYR61, and integrin β2 (2-4), the inhibitor of apoptosis protein (IAP) survivin (5), the mechano-sensitive nuclear envelope protein Lamin B2 (6), and the oncogenic receptor tyrosine kinase Axl (7).
- Holden, J.K. and Cunningham, C.N. (2018) Cancers (Basel) 10, .
- Zhang, H. et al. (2009) J Biol Chem 284, 13355-62.
- Chan, S.W. et al. (2011) J Biol Chem 286, 7018-26.
- Chan, S.W. et al. (2011) Oncogene 30, 600-10.
- Zhang, W. et al. (2015) Cancer Res 75, 4450-7.
- Zanconato, F. et al. (2015) Nat Cell Biol 17, 1218-27.
- Cui, Z.L. et al. Int J Immunopathol Pharmacol 25, 989-1001.
Background References
Trademarks and Patents
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