| Product Includes | Product # | Quantity | Mol. Wt | Isotype/Source |
|---|---|---|---|---|
| PARP (46D11) Rabbit mAb | 9532 | 20 µl | 116, 89 kDa | Rabbit |
| AIF (D39D2) XP® Rabbit mAb | 5318 | 20 µl | 67 kDa | Rabbit IgG |
| MIF (E8S8H) Rabbit mAb | 75038 | 20 µl | 12 kDa | Rabbit IgG |
| Poly/Mono-ADP Ribose (E6F6A) Rabbit mAb | 83732 | 20 µl | Rabbit IgG | |
| Anti-rabbit IgG, HRP-linked Antibody | 7074 | 100 µl | Goat |
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Description
The Parthanatos Antibody Sampler Kit provides an economical means of detecting the activation of parthanatos. The kit includes enough antibodies to perform two western blot experiments with each primary antibody.
Storage
Background
Parthanatos is a form of regulated cell death that follows a multistep cascade and is triggered by the accumulation of poly (ADP-ribose) (PAR). When PAR polymerase-1 (PARP-1) is overactivated under certain conditions, excessive PAR is produced and binds to apoptosis-inducing factor (AIF). As a result, AIF is released from the mitochondria and forms a complex with macrophage migration inhibitory factor (MIF). Subsequently, the AIF/MIF complex is translocated to the nucleus where MIF cleaves genomic DNA into large fragments, and cell death follows (1-3). Studies have found that parthanatos is involved in the pathogenesis of many diseases, particularly neurodegenerative disorders, such as Alzheimer's disease, Huntington's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS) (4-7).
- Fatokun, A.A. et al. (2014) Br J Pharmacol 171, 2000-16.
- Wang, Y. et al. (2016) Science 354, aad6872. doi: 10.1126/science.aad6872.
- Liu, L. et al. (2022) Cell Mol Life Sci 79, 60.
- Park, H. et al. (2020) Int Rev Cell Mol Biol 353, 1-29.
- Wang, X. and Ge, P. (2020) Neuroscience 449, 241-250.
- Zhou, Y. et al. (2021) Pharmacol Res 163, 105299.
- Thapa, K. et al. (2021) Life Sci 267, 118975.
Background References
Trademarks and Patents
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