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翻译调控和 RNA 调节

翻译调控和 RNA 调节

通过转录后和翻译调控来调节基因表达,以调节各种细胞过程,包括发育、细胞分化和代谢。转录后修饰和信使RNA (mRNA)的加工调节mRNA分子的丰度和定位以及mRNA到蛋白质的下游翻译。RNA 生命周期由多种 RNA 结合蛋白 (RBP) 调节,这些蛋白对于确保准确和碱性基因表达至关重要。这些 RBP 和过程的失调可导致大量人类疾病,例如癌症、神经退行性疾病(包括阿尔茨海默病)、脊髓性肌肉萎缩、肌萎缩性侧硬化症 (ALS) 和自身免疫性疾病。与 Cell Signaling Technology (CST) 合作,通过检测 RBP 和 RNA 修饰的抗体获得高质量的数据,从而支持了解 RNA 生命周期控制过程的研究。

RNA 修饰

RNA modifications are critical for post-transcriptional regulation of gene expression during multiple cellular processes, including development and cell differentiation. Recent advances have made it possible to investigate RNA modifications, however, obtaining high quality data requires accurate and validated antibodies. CST offers a variety of reliable antibodies for RNA modifications and associated writer, reader, and eraser proteins to support your research into the functions of RNA modifications.

RNA 加工

Many types of RNA, including transfer RNA (tRNA), ribosomal RNA (rRNA), microRNA (miRNA) and long non-coding RNA (lncRNA) require modification or processing in order to perform their functions in the cell. For example, tRNAs are modified and conjugated to amino acids prior to functioning in protein translation. rRNAs are bound by RNA-binding proteins to assemble into ribosomes prior to protein translation. Multiple cellular functions and disease mechanisms are influenced by RNA processing. By offering a variety of validated antibodies for RNA binding proteins, CST is your expert source of reagents for investigations into understanding the mechanisms governing RNA processing.

RNA 剪接、加帽和聚腺苷酸化产品

In order for RNA to encode for a protein, it must be modified via capping, polyadenylation, and splicing before it can be transported into the cytoplasm for translation. Changes to this process can lead to genetic variation and increased disease risk. CST has a diverse catalog of products that can support your ability to monitor modulation of mRNA fate through alternative splicing, polyadenylation, and capping by RNA binding proteins.

RNA 稳定性和解密

Regulation of the stability and decay of RNA by surveillance mechanisms is vital to ensuring fidelity of genetic information flow. Disruption of this process results in a host of diseases ranging from neurodegeneration to cancer. CST provides a wide variety of reliable and validated antibodies for investigating the dynamics of RNA stability and decay as it applies to cell cycle processes, cellular differentiation, stress and immune responses.

RNA 转运

Multiple classes of RNA can be transported from different locations, giving precise spatial and temporal control of gene expression in a cell. Localizing RNA is critical in many essential cellular functions including cell fate determination, directed cell movement, and tissue functionality. RNA visualization methods have revolutionized the investigation of RNA dynamics in cells. Let CST provide you the best validated antibodies to interrogate RNA transport pathways.

翻译调控

Translational control is a key component in essential cellular processes that maintain homeostasis - the disruption of which leads to human disease. The role of RNA in translational control supports the modulation of protein synthesis and protein factors which assist in metabolic function. CST provides a diverse and validated catalog of antibodies to probe mechanisms by which RNA and its proteins regulate translational control.

小包装抗体套装

Our sampler kits have been carefully curated to obtain reliable data in your research evaluating multiple proteins involved in RNA regulation and translational control. These are an economical option for evaluating many aspects of gene expression by western blotting.

检测试剂盒

CST provides a wide-ranging catalog of ELISA assays and antibody duets to evaluate the essential role of RNA binding proteins in translation, transcription, and degradation, as well as gene expression. Our expert scientists can provide direction on designing an assay or choosing the right ELISA assay to interrogate RNA functions and the effects on physiology and pathology.

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