产品结果

纤维化

纤维化是对慢性炎症的致病反应,包括细胞外基质(ECM)沉积和组织硬化过多,可导致器官功能障碍、发病和死亡。多种刺激,包括感染、自身免疫反应、毒素、辐射和机械损伤,都可能导致纤维化。不幸的是,导致纤维化的机制尚未完全清楚,对有效治疗该疾病构成了重大挑战。Cell Signaling Technology (CST) 和我们的专家科学家帮助提供高质量、经过验证的抗体和产品,以支持您的纤维化研究。

纤维化中的抗体信号通路

When developing therapeutics, it is important to understand the signaling pathways that contribute to the activation and maintenance of fibrotic cells such as myofibroblasts. CST offers a variety of validated antibodies to probe key fibrotic pathways to support your discovery research.

用于纤维化代谢的抗体

Metabolic changes are associated with fibrosis in a variety of organ types. Cell Signaling Technology (CST) offers a diverse selection of validated antibodies to advance the discovery and development of novel treatments targeting fibrotic metabolism.

纤维化中的免疫应答抗体

Although the relationship between inflammation and fibrosis is deeply interconnected and has many overlapping mechanisms, the interplay between them is poorly understood. CST offers a wide variety of antibodies that can support your research into the immune-driven aspects of fibrosis pathogenesis.

细胞外基质蛋白抗体

Extracellular matrix (ECM) is essential for normal tissue and cellular function and plays a role in differentiation, metabolism, proliferation, however, excessive accumulation can drive the progression of fibrosis. CST offers a diverse catalog of validated antibodies to better understand ECM proteins in support of your fibrosis research.

纤维化中细胞死亡的抗体

There is increasing evidence that cell death can contribute to fibrosis at several stages - initiation, progression, and resolution of disease. CST provides validated antibodies to reliably measure cell death and the underlying mechanisms of fibrosis.

纤维化中的肿瘤微环境抗体

Fibrotic tissue in the tumor microenvironment (TME) supports cancer progression, survival, and metastasis. CST offers a diverse selection of antibodies to interrogate the architecture of the TME.

细胞骨架蛋白抗体

During fibrosis, activation of fibroblasts to become myofibroblasts is marked by changes in the cellular cytoskeleton. Activated fibroblasts are characterized by the expression of alpha smooth actin and the deposition of excessive collagens, fibronectin, and other components into the ECM. The validated and reliable antibodies offered by CST can be used to probe the proteins involved in the underlying changes of pro-fibrotic cells.

分析和试剂盒

Assessing fibrotic activity by measuring collagen content and signaling molecules provides important information to advance the discovery of novel therapeutic targets. CST has reliable, time-saving assays to measure changes in protein expression and signaling to help advance fibrotic discovery research.