Control peptides can be used to ensure reproducibility in proteomics experiments conducted with PTMScan.
What if an antibody could identify a PTM, regardless of the flanking amino acid sequence? This innovative idea is the basis of CST's PTMScan product line.
PTMScan Motif Antibody Kits from Cell Signaling Technology
PTMScan Motif Antibodies and Kits, for customers who purchase a license and would like to perform PTMScan Proteomics in-house.
Overview of methodology and client deliverables for the PTMScan Direct Proteomic Service offered by Cell Signaling Technology.
Features, benefits, and product listing for PTMScan Direct Proteomic Services for the targeted screening of defined protein sites critical for drug and biomarker discovery.
Immunoaffinity purification of PTM peptides for mass spectrometry-based proteomics--PTMScan
CST PTMScan tutorial video explains how to use antibodies to quickly and efficiently enrich PTM peptides for mass spectrometry-based proteomics
PTMScan® Glycosylation
PTMScan videos and links to complementary technologies for phospho-peptide enrichment and Science Webinar on Proteomics and Cell Signaling.
Identifies and quantifies up to many hundreds of critical signaling nodes across pathways involved in cancer biology, immune cell signaling, and more.
Information and case study data for the PTMScan Direct Apoptosis/Autophagy Service offered by CST.
Matthew Stokes, Ph.D., and Christopher Rose, Ph.D. introduce Cell Signaling Technology’s PTMScan® method and provide a demonstration of its applications.
A video tutorial illustrating the methodology behind PTMScan Technology and an example of its use in a recent phosphoproteomic study authored by scientists from CST.
This video introduces PTMScan technology, a platform for the enrichment of post-translational modifications (PTMs) in mass spectrometry-based proteomics studies.
CST can identify and quantify thousands of post-translational modification sites specific to your sample—phosphorylation, ubiquitination, acetylation, and more.
PTMScan® Sumoylation Remnant Motif Kit - SUMOylation Proteomics
This video describes the simplified PTMScan® HS workflow for LC-MS analysis of ubiquitination and SUMOylation that improves readout sensitivity, reduces sample prep time, and eliminates lyophilization, 9M urea, and antibody elution steps.
Information and case study data for the PTMScan Direct Cell Cycle and DNA Damage Service offered by CST.
Nov 2008, Renewal of a research agreement with Ortho-Biotech Oncology Research & Development, under which CST will employ its patented PhosphoScan® and PTMScan® technologies in research aimed at biomarker discovery and validation for multiple enzyme target classes and lead small-molecule inhibitors.
Through in-house testing, we have found that the magnetic beads from our PTMScan HS kits aggregate and stick to the walls of some specific brands of tubes. Moreover, they cannot be washed off or spun off the sides of the tubes. This is an issue with specific brands of tubes themselves and not an inherent issue with the PTMScan bead product. Therefore, the following brands of polypropylene tubes are NOT recommended with magnetic bead PTMscan HS kits: 1. CellTreat #229441, polypropylene 1.5mL tube, non-sterile, non-pyrogenic2. Denville Scientific (Harvard Bioscience) #C3171, 1.5mL Posi-Lock tubes, polypropyleneThe following brand of microcentrifuge tubes is compatible with magnetic bead PTMscan HS kits:1. USA scientific tubes #1615-5500
Learn about the history of Cell Signaling Technology and our commitment to providing reproducible tools to move your science forward.
Mass spectrometry-based proteomic methods like PTMScan can be applied in translational research. For example to identify novel biomarkers of disease
To study pathways regulated by nitrotyrosine, CST offers two recombinant monoclonal antibodies against the same PTM for WB and proteomic applications.
Lymphoma is a cancer of the lymphatic system, a key part of the body’s immune system. Treatment options & patient prognoses differ based on lymphoma type.
Information on KinomeView western blotting service offered by Cell Signaling Technology that uses Phospho-Motif Antibodies to provide a kinome-wide view of cellular phosphorylation.
